Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway
- 1 December 2005
- journal article
- Published by Elsevier in Mechanisms of Ageing and Development
- Vol. 126 (12) , 1305-1313
- https://doi.org/10.1016/j.mad.2005.07.009
Abstract
No abstract availableKeywords
This publication has 35 references indexed in Scilit:
- Toll-like receptor control of the adaptive immune responsesNature Immunology, 2004
- Innate immunity in aging: impact on macrophage functionAging Cell, 2004
- Aging and innate immune cellsJournal of Leukocyte Biology, 2004
- Age-related changes in lymphocyte development and functionNature Immunology, 2004
- Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune systemJournal of Leukocyte Biology, 2004
- The PHD Domain of MEKK1 Acts as an E3 Ubiquitin Ligase and Mediates Ubiquitination and Degradation of ERK1/2Molecular Cell, 2002
- IFN-γ–dependent transcription of MHC class II IA is impaired in macrophages from aged miceJournal of Clinical Investigation, 2001
- The p38 Mitogen-activated Protein Kinase Is Required for NF-κB-dependent Gene ExpressionJournal of Biological Chemistry, 1999
- Age-Related Reductions in the Activation of Mitogen-Activated Protein Kinases p44mapk/ERK1 and p42mapk/ERK2 in Human T Cells Stimulated via Ligation of the T Cell Receptor ComplexCellular Immunology, 1996
- Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural and synthetic bacterial products.The Journal of Experimental Medicine, 1993