Effects of Cisapride on Colonic Transit in Patients with Progressive Systemic Sclerosis
- 1 August 2002
- journal article
- clinical trial
- Published by Springer Nature in Clinical Rheumatology
- Vol. 21 (4) , 271-274
- https://doi.org/10.1007/s100670200072
Abstract
Progressive systemic sclerosis (PSS) may involve any portion of the gastrointestinal tract, including the colon. Constipation is common in patients with PSS. Cisapride, a benzamide derivative, is a potentially useful agent in the treatment of chronic idiopathic constipation. The effect of cisapride on colonic transit was evaluated in 16 PSS patients by a radionuclide colonic transit method. Each patient received cisapride orally three times a day for a week. The results showed acceleration in colonic transit in response to cisapride. We conclude that cisapride is effective in the treatment of constipation in patients with PSS.Keywords
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