Gross Physical Properties of Emulsified Influenza Virus Vaccines and the Adjuvant Response

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Abstract
Summary: A variety of formulas were used to obtain emulsified influenza, PR8, virus vaccines which exhibited different physical properties. The relation between the gross physical properties of these water-in-oil emulsions and their adjuvant effect following subcutaneous injection of mice was studied. The relation between emulsion viscosity and adjuvant effect was a strainghtforward one: extremely high emulsion viscosity reduced the adjuvant effect. On the other hand, the relation between stability and the adjuvant effect seemed more complex. The results of these experiments were consistent with the proposition that optimal emulsion stability promotes maximum adjuvant effect. The consistency with which an adjuvant effect was obtained with water-in-mineral oil emulsified vaccines of different viscosity and stability was remarkable.

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