Fragmentation of DNA in P388D1 macrophages exposed to oxidised low‐density lipoprotein
- 18 October 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 332 (3) , 218-220
- https://doi.org/10.1016/0014-5793(93)80635-8
Abstract
Exposing a macrophage‐like murine cell line to copper‐oxidised low‐density lipoprotein led to DNA fragmentation which was inhibited by the putative Ca2+/Mg2+ endonuclease inhibitor, zinc sulphate. DNA fragmentation preceded loss of membrane impermeability. These results suggest that apoptosis may be a mechanism of macrophage foam cell death in atherosclerotic lesions in the arterial wall.Keywords
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