Mast Cells in Bronchial Connective Tissue of Man: Their Modifications in Asthma and after Treatment with the Histamine Liberator 48/80

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Abstract
Bronchial biopsies were taken from 6 asthmatic and 11 non-asthmatic individuals, and the mast cells stained in these specimens with toluidine blue and counted. The preparations from asthmatics showed fewer mast cells to a statistically significant degree than those from non-asthmatics. Intravenous injection of compound 48/80 diminished the degree of granulation, though there were no significant differences between the specimens of allergic and non-allergic persons.