Intraventricular administration of nerve growth factor induces ornithine decarboxylase in peripheral tissues of the rat.
- 1 May 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (5) , 2512-2515
- https://doi.org/10.1073/pnas.75.5.2512
Abstract
Intraventricular administration of nerve growth factor [NGF] causes an increase in the activity of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) in liver, kidney and adrenal as well as in brain itself. An increase in the concentration of corticosterone in the blood was also observed. Adrenalectomy, hypophysectomy, or pituitary stalk section inhibits the increase of ornithine decarboxylase activity in the peripheral tissues. Ornithine decarboxylase activity in the brain, however, responds to NGF in these animals. NGF causes an activation of the hypothalamo-hypophyseal endocrine system.This publication has 18 references indexed in Scilit:
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