Effects of Pyridoxine and Desoxypyridoxine on Magnesium Metabolism in the Rabbit.

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Abstract
External balnce studies for Mg and isotopic determinations of the exchangeable Mg content of the body were made in 8 adult male rabbits before and after 8 daily injections of pyridoxine(lOOmg), and in another group of 8 rabbits before and after 6 daily injections of desoxypyridoxine, 40 mg/kg. Except for an increase in mean body weight in the group receiving pyridoxine, no significant changes were observed in the studies made on these 16 rabbits. In 8 animals given 2 intravenous injections of pyridoxine (100 mg) 24 hr. apart, the relative tissue activity of Mg28 was increased in the appendix and the heart. In 15 rabbits given desoxypyridoxine, 40 mg/kg, daily for 7 days, there was a significant decrease in the relative tissue activity in kidney, lung, and bone, and a significant increase in the serum Mg concentration. The results suggest that an excess or a deficiency of pyridoxine alters the rate of uptake of Mg28 by various tissues.

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