Loperamide Modifies Escherichia coli, Heat-Stable Enterotoxin-Induced Intestinal Secretion
- 1 December 1982
- journal article
- clinical trial
- Published by Wiley in Journal of Pediatric Gastroenterology and Nutrition
- Vol. 1 (4) , 583-586
- https://doi.org/10.1097/00005176-198212000-00023
Abstract
We have shown previously that loperamide, an opiate analogue, inhibits cholera-toxin- and prostaglandin E2-induced secretion in the rat small intestine. In these studies loperamide modified secretion induced by partially purified Escherichia coli, heat-stable enterotoxin in infant mice. The drug was effective whether administered before or after established secretion. These experiments provide further suggestive evidence that loperamide has a broad spectrum of antisecretory activity.Keywords
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