Idiopathic Central Precocious Puberty in Girls as a Model of the Effect of Plasma Estradiol Level on Growth, Skeletal Maturation and Plasma Insulin-Like Growth Factor I
- 1 January 1991
- journal article
- endocrinology of-puberty
- Published by S. Karger AG in Hormone Research
- Vol. 36 (3-4) , 116-120
- https://doi.org/10.1159/000182143
Abstract
Girls suffering from idiopathic central precocious puberty (CPP) may have different levels of estrogenic activity. This study was performed to evaluate the relationship between the estrogenic activity and the hypothalamopituitary activation and the effect of various plasma estradiol (E2) levels on growth, skeletal maturation and plasma insulin-like growth factor I (IGF-I). Fifty-eight girls with CPP were divided into 2 groups: group I with E2 0.5 and 2 (r = 0.41, p 2 level. Conversely, the mean plasma IGF-I values were lower in group I (2.4 ± 0.3 U/ml) than in group II (4.2 ± 0.6 U/ml, p 2(r = 0.52, p 2 and peak LH/FSH ratios indicates variable degrees of hypothalamopituitary-ovarian activation and that low E2 stimulates growth in spite of prepubertal IGF-I values, suggesting a direct effect of E2 on skeletal growth.Keywords
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