Palladium-Phosphinous Acid Catalyzed Cross-Coupling of Aryl Halides Using a Hypervalent Phenylsilane in Water
- 13 July 2005
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 2005 (14) , 2287-2292
- https://doi.org/10.1055/s-2005-870013
Abstract
A palladium-phosphinous acid catalyzed NaOH-promoted cross-coupling methodology that affords biaryls from tetrabutylammonium triphenyldifluorosilicate and aryl halides in good to high yields has been developed. The coupling proceeds in aqueous 0.5 M NaOH solution in the absence of organic co-solvents and does not require inert atmosphere, which greatly facilitates operation and catalyst handling.Keywords
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