Prostaglandin and Thromboxane Production in Ovarian Cancer Tissue
- 1 January 1984
- journal article
- research article
- Published by S. Karger AG in Gynecologic and Obstetric Investigation
- Vol. 18 (5) , 225-229
- https://doi.org/10.1159/000299085
Abstract
Tissue contents of prostaglandin E2 (PGE2), thromboxane B2 (TxB2, a metabolite of proaggregatory thromboxane A2) and 6-keto-PGF1Α (a metabolite of antiaggregatory pros-tacyclin, PGI2) were measured from ovarian cancer (n = 13), borderline malignant (6), benign ovarian tumor (17) and normal ovary (6) of postmenopausal women. TxB2 contents were significantly (p < 0.05) increased in metastatic ovarian cancer tissue, compared to local ovarian cancer, borderline malignant, benign tumor or normal ovarian tissues, while in 6-keto-PGF1Α production there was no difference between these groups. PGE2 contents were also increased in metastatic ovarian cancer tissue. These data suggest the association between local PG production and advanced ovarian cancer tissue.Keywords
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