Changes in brain concentrations of catecholamines and indoleamines inToxoplasma gondiiinfected mice
- 1 January 1985
- journal article
- research article
- Published by Taylor & Francis in Pathogens and Global Health
- Vol. 79 (2) , 153-157
- https://doi.org/10.1080/00034983.1985.11811902
Abstract
Brain concentrations of dopamine, homovanillic acid, norepinephrine, serotonin and 5-hydroxy-indoleacetic acid were measured in mice with acute and chronic, adult-acquired toxoplasmosis. Mice with acute infections showed a 40% rise in homovanillic acid levels as compared with controls; dopamine levels, however, remained unchanged. Norepinephrine levels in this group were 28% lower than in controls. Dopamine levels were 14% higher in the mice with chronic infections than controls. Serotonin and 5-HIAA levels were not altered in infected mice. These neurochemical changes may be factors contributing to mental and motor abnormalities that accompany or follow toxoplasmosis in rodents and possibly in man.This publication has 6 references indexed in Scilit:
- The effect of congenital and adult-acquiredToxoplasmainfections on the motor performance of micePathogens and Global Health, 1983
- ChronicToxoplasmainfections and motor performance in the mousePathogens and Global Health, 1980
- Environment and central neurotransmitters in relation to learning, memory and behaviorGeneral Pharmacology: The Vascular System, 1979
- INCREASED DOPAMINE CONCENTRATION IN LIMBIC AREAS OF BRAIN FROM PATIENTS DYING WITH SCHIZOPHRENIABrain, 1979
- Learning capacity and memory of normal andToxoplasma-infected laboratory rats and miceZeitschrift Fur Parasitenkunde-Parasitology Research, 1979
- DOPAMINE IN THE BASAL GANGLIA: Its Role and Therapeutic Implications (Including the Clinical Use of L-DOPA)British Medical Bulletin, 1973