Ubiqutination of the transcriptional coactivator p300 during retinic acid induced differentiation

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Abstract
Trascriptional coactivator p300 plays an important role in differentiation processes of various cell lines. In this report, we examined levels of p300 protein and the related protein, CREB binding protein (CBP), during the retinoic acid (RA)-induced differentiation of F9 cell. As a result, the level of p300 protein began to decrease at 36 h after treatment with RA dramatically, however, the level of CBP protein did not alter. Moreover, ubiquitinated p300 protein was only detected in differentiated F9 cells. These results suggest that p300 protein is possibly degraded via the ubiquitin-dependent pathway during the RA-induced differentiation of F9 cells.

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