Cross‐Idiotypic Reactions Among Anti‐Rh (D) Antibodies

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Abstract
In a series of experiments several idiotypic-specific rabbit antisera produced against different Ig[immunoglobulin]G anti-Rh (D) antibodies reacted with other anti-Rh (D) antibodies and thus showed cross-idiotypic reactions. Some of the antisera agglutinated almost all types of anti-D-sensitized erythrocytes, whereas other idiotypic-specific antisera agglutinated only a few anti-D-sensitized erythrocytes. Anti-D antibodies showed several different cross-idiotypic reaction patterns. The cross-idiotypic antigens were, in most instances, localized to the heavy chains only. In a few cases, the cross-idiotypic antigens were dependent on the interaction between heavy and light chains.