The absorption of aliphatic carbamates from the rat colon
- 1 September 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 30 (1) , 638-641
- https://doi.org/10.1111/j.2042-7158.1978.tb13346.x
Abstract
The colonic absorption of a series of aliphatic carbamates has been studied using an in situ preparation in the rat. The absorption process appeared to be passive and no metabolism by the colon membrane was detected. A linear correlation between the logarithms of the absorption rate constants and apparent partition coefficients was found. The absorption rates were not affected by concurrent water flux.This publication has 3 references indexed in Scilit:
- Transmucosal fluid movement and its effect on drug absorption.CHEMICAL & PHARMACEUTICAL BULLETIN, 1975
- Mechanism and site of vitamin K-3 small intestinal transportAmerican Journal of Physiology-Legacy Content, 1974
- Drug Absorption I: An In Situ Rat Gut Technique Yielding Realistic Absorption RatesJournal of Pharmaceutical Sciences, 1969