Different striatal dopamine D2 receptor occupancy in alcohol dependent patients with or without physical withdrawal symptoms - a study using IBZM-SPECT
- 1 September 2002
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 109 (9) , 1215-1219
- https://doi.org/10.1007/s00702-002-0749-9
Abstract
Ten male patients with type I alcohol dependency fulfilling DSM-IV criteria for alcohol dependency were investigated twice using IBZM-SPECT after alcohol withdrawal (day 2 and day 28 after withdrawal). Five patients had a history of physical withdrawal symptoms, 5 patients had no such history. The group with physical withdrawal symptoms showed higher IBZM binding in both scans indicating differences of dopaminergic neurotransmission in different subtypes of alcohol dependency.Keywords
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