Biosynthesis of the C-nucleoside, minimycin: Asymmetric incorporation of glutamate and acetate into the oxazine ring.

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Abstract
The biosynthesis of the C-nucleoside antibiotic, minimycin, by Streptomyces hygroscopicus was reinvestigated. Carbons 3, 4 and 5 of glutamate are incorporated asymmetrically into carbons 6, 5 and 4 of the oxazine ring of the antibiotic.