More flexible sequential and non-sequential designs in long-term clinical trial
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Communications in Statistics - Theory and Methods
- Vol. 13 (19) , 2339-2353
- https://doi.org/10.1080/03610928408828830
Abstract
In this paper, we describe decision making procedures as they exist in most clinical trials,review some recently suggested approaches to monitoring and clarify how these methods allow greater flexibility in monitoring and explicit specification of data monitoring methods in the protocol.Keywords
This publication has 5 references indexed in Scilit:
- Discrete Sequential Boundaries for Clinical TrialsBiometrika, 1983
- Two-Sample Repeated Significance Tests Based on the Modified Wilcoxon StatisticJournal of the American Statistical Association, 1982
- Repeated Significance Testing for a General Class of Statistics Used in Censored Survival AnalysisJournal of the American Statistical Association, 1982
- Group sequential methods in the design and analysis of clinical trialsBiometrika, 1977
- Nonparametric Testing Under Progressive Censoring*Calcutta Statistical Association Bulletin, 1973