Desmopressin as a test of urinary Concentrating ability in pregnancy

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Abstract
Desmopressin is a synthetic analogue of vasopressin with a prolonged antidiuretic effect; 20 μg were given intranasally to 7 normal healthy volunteers and to 80 pregnant women to assess its safety and efficacy in pregnancy as a test of renal concentrating ability. There were 27 normal pregnancies, 18 with hypertension and 35 with bacteriuria. It did not produce hypertension, oliguria or other unwanted effects. Direct comparison showed that desmopressin was more effective in assessing renal concentrating ability during pregnancy than was 15 hours of dehydration, and was comparable with published data for 24 hours of dehydration or intramuscular vasopressin.