COMPARISON OF CARCINOGENICITY OF N-ALKYL-N'-NITRO-N-NITROSO-GUANIDINES

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 69  (2) , 277-279
Abstract
Carcinogenicity of 7 homologs of N-alkyl-N''-nitro-N-nitrosoguanidine (N-alkyl-NNG), namely, N-methyl-NNG, N-propyl-NNG, N-butyl-NNG, N-isobutyl-NNG, N-pentyl-NNG and N-hexyl-NNG, was examined by injecting the compounds s.c. into rats. All of them except N-isobutyl-NNG and N-hexyl-NNG were carcinogenic, but N-ethyl-NNG followed by N-methyl-NNG were stronger carcinogens than those with longer alkyl chains.

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