Hypersensitivity to a Synthetic Polypeptide: Induction of a Delayed Reaction

22 March 1963

journal article
research article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 139 (3560) , 1222-1223
https://doi.org/10.1126/science.139.3560.1222

Abstract

A multichain copolypeptide, p (Tyr,Glu)-pAla-- p Lys, induced in guinea pigs a prolonged state of delayed hypersensitivity not associated with detectable circulating antibodies. Cross reactions of the delayed type were observed with chemically related polypeptides.

Keywords

This publication has 11 references indexed in Scilit:

Studies on the chemical basis of the antigenicity of proteins. 6. Antigenic specificity of some synthetic polypeptides containing tyrosine
Biochemical Journal, 1963
Studies on the chemical basis of the antigenicity of proteins. 5. Synthesis, characterization and immunogenicity of some multichain and linear polypeptides containing tyrosine
Biochemical Journal, 1962
A Theory of Delayed Hypersensitivity
Science, 1962
DELAYED HYPERSENSITIVITY TO HAPTEN-PROTEIN CONJUGATES
The Journal of Experimental Medicine, 1962
IMMUNOLOGICAL SPECIFICITY OF DELAYED AND IMMEDIATE HYPERSENSITIVITY REACTIONS
The Journal of Experimental Medicine, 1962
Studies on Synthetic Polypeptide Antigens
Published by Elsevier ,1961
Delayed Hypersensitivity to Simple Protein Antigens
Published by Elsevier ,1961
A specific synthetic polypeptide antigen
Biochimica et Biophysica Acta, 1960
A strongly antigenic synthetic polypeptide
Journal of Molecular Biology, 1960
A Quantitative Study of Passive Anaphylaxis in the Guinea Pig
The Journal of Immunology, 1942