Anaphylaxis in the Fish

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Abstract
Summary: It has been shown that it is possible to sensitize several species of teolost fish to protein antigens as represented by horse serum and egg albumen. This sensitivity is demonstrated by a characteristic reaction which has been described.* That this reaction is on the basis of hypersensitivity has been shown because it is specific for the various antigens used; an incubation period is necessary before hypersensitivity may be shown to be present, it can be diminished by the effect of anaesthesia and modified by the action of epinephrine and ephedrine, and finally it can be simulated by the administration of histamine. The fact that benadryl, pyribenzamine and neohetramine do not affect the reaction does not invalidate this hypothesis as it is well known that these drugs do not affect many clinical allergic states. Hypersensitive reactions could not be demonstrated in the frog. In vitro anaphylactic reactions, using isolated heart and muscle preparations, could not be demonstrated in fish and frogs.

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