Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation
- 1 December 2009
- journal article
- research article
- Published by Elsevier in Cancer Cell
- Vol. 16 (6) , 463-474
- https://doi.org/10.1016/j.ccr.2009.10.016
Abstract
No abstract availableKeywords
This publication has 58 references indexed in Scilit:
- Class I PI3K in oncogenic cellular transformationOncogene, 2008
- Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysNature, 2008
- Structural comparisons of class I phosphoinositide 3-kinasesNature Reviews Cancer, 2008
- A membrane capture assay for lipid kinase activityNature Protocols, 2007
- Rare cancer-specific mutations in PIK3CA show gain of functionProceedings of the National Academy of Sciences, 2007
- A PI3K activity-independent function of p85 regulatory subunit in control of mammalian cytokinesisThe EMBO Journal, 2006
- Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTENProceedings of the National Academy of Sciences, 2006
- The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolismNature Reviews Genetics, 2006
- Exploiting the PI3K/AKT Pathway for Cancer Drug DiscoveryNature Reviews Drug Discovery, 2005
- Coot: model-building tools for molecular graphicsActa Crystallographica Section D-Biological Crystallography, 2004