CEFOXITIN FOR PROPHYLAXIS IN PREMENOPAUSAL WOMEN UNDERGOING VAGINAL HYSTERECTOMY

  • 1 January 1980
    • journal article
    • research article
    • Vol. 56  (5) , 629-634
Abstract
To determine the unbiased incidence and types of postoperative infection and their alteration(s) by antimicrobial prophylaxis, a prospective double-blind study was performed using perioperative i.m. cefoxitin or placebo given to premenopausal women undergoing vaginal hysterectomy. The clinical and surgical profiles of the 2 groups of women were similar, but there were marked differences in their postoperative clinical courses. Only 8% of the 50 women given cefoxitin had major postoperative infection, compared to 57% of the 49 women given placebo (P < 0.001); this was associated with a 2.8 day reduction in the hospital stay for those given cefoxitin (P < 0.001). No clinically significant side effects were observed.

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