A novel monolayer cell line derived from human umbilical cord blood cells shows high sensitivity to measles virus
- 1 May 2007
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 88 (5) , 1565-1567
- https://doi.org/10.1099/vir.0.82758-0
Abstract
Measles virus (MeV) research is largely dependent on the B95a cell line, which is derived from marmoset B lymphocytes. As this cell line is persistently infected with Epstein–Barr virus (EBV), a novel cell line, COBL-a, was established from human umbilical cord blood. COBL-a cells have a significant advantage over B95a cells because they are of human origin, are free from EBV and have higher sensitivity to wild-type MeV. Thus, COBL-a cells should prove very valuable for both epidemiological and basic studies of MeV.Keywords
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