Endogenous Creatinine Clearance by Rats.

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Abstract
Thirty-one white male albino rats of weights ranging from 200 to 450 g were used to study 24-hr, undisturbed creatinine clearances. Determinations were made using apparent creatinine, true serum and apparent urinary creatinine and true serum and urinary creatinine. The resting creatinine clearance was 0.709 ml/min/100 g body weight, using true serum creatinine and apparent urinary creatinine. The urinary non-creatinine chromogen averaged 7.3% of the total chromogen; under some circumstances this value is sufficiently large to be significant. Correlations of creatinine clearance with body weight, kidney weight, and surface area were approximately the same. In this weight range it seems most practical to use body weight as the unit for relating clearances.

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