Hyperuricemia in Mongolism

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Abstract
MONGOLISM has recently been investigated for disorders of purine metabolism. Although the numbers of patients studied is small, a correlation appears to exist between hyperuricemia and mongolism.Mertz, Fuller and Concon,1 in 25 patients with mongolism, two to twelve years of age, found a mean serum uric acid of 5.42 mg. as compared to 3.87 mg. per 100 ml. in mentally retarded controls without mongolism from the same institution. This seemed to be a highly significant increase (p less than 0.005). Earlier, Fuller, Luce and Mertz2 reported similar results in 40 older patients with mongolism. Appleton et al.3 discovered similar . . .