Melanocytic bronchial carcinoid tumor
- 15 October 1980
- Vol. 46 (8) , 1843-1848
- https://doi.org/10.1002/1097-0142(19801015)46:8<1843::aid-cncr2820460823>3.0.co;2-c
Abstract
A melanin- and serotonin-producing bronchial carcinoid tumor is described. Melanin synthesis by neoplastic cells also containing electron-dense core (neurosecretory) granules was documented by electron microscopy and serotonin content was found by biochemical assay to be 201.2 μg/g wet weight of tissue. Simultaneous demonstration of “endocrine” properties with characteristics of a cell of neuralcrest origin provides strongly confirmatory evidence for the APUD cell theory of Pearse and makes an interesting commentary in regard to general theories of neoplasia.This publication has 10 references indexed in Scilit:
- Malignant melanoma producing serotoninCancer, 1979
- Pigmented carcinoid tumour of the thymusHistopathology, 1977
- Carcinoid apudomasCurrent Problems in Cancer, 1977
- Neurocristopathy, neuroendocrine pathology and the APUD conceptZeitschrift für Krebsforschung und Klinische Onkologie, 1975
- Bronchial carcinoid with choroidal metastasis in an adolescent.Case report and ultrastructural studyCancer, 1974
- The Melanocyte: Its cytochemical and immunological relationship to cells of the endocrine polypeptide (APUD) seriesVirchows Archiv B Cell Pathology, 1969
- Gene Regulation for Higher Cells: A TheoryScience, 1969
- Medullary cancer of the thyroid gland associated with hypercorticismCancer, 1969
- THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPTJournal of Histochemistry & Cytochemistry, 1969
- Common cytochemical and ultrastructural characteristics of cells producing polypeptide hormones (the APUD series) and their relevance to thyroid and ultimobranchial C cells and calcitoninProceedings of the Royal Society of London. B. Biological Sciences, 1968