Changes in Renal Hemodynamics Associated with the Intravenous Administration of Sodium para-Aminohippurate

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Abstract
The renal hemodynamic changes occurring during the measurement of the tubular excretory max. for p-aminohippurate (TmPAH) were detd. in a group of normal human subjects. Also, the pulse rate and blood pressure were detd. before, during and for 23 min. after the injn. of the TmPAH priming dose. During the measurement of TmPAH there was a significant decrease in mean glomerular filtration rate (-13%) for 17 subjects and a significant increase in the mean renal plasma flow (14%) for 10 subjects studied with right renal vein catheterization. Significant increases in systolic and diastolic blood pressure and pulse rate accompanied and followed the intraven. admn. of the priming dose of 50 cc. of 20% PAH in 10 subjects.

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