Juvenile Pernicious Anemia

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Abstract
THE occasional occurrence of megaloblastic anemia in early childhood was recognized at least thirty years ago, but the relative rarity of cases and the paucity of knowledge of their pathogenesis prevented adequate understanding and classification. Many of the cases were ultimately demonstrated to be the result of folic acid deficiency.1 A few seemed to fulfill the criteria for classic pernicious anemia. In 1937 Langmead and Doniach2 described an infant who was thought to have true pernicious anemia, and in 1940 Pohl3 presented evidence that his thirteen-year-old patient lacked intrinsic factor. Subsequently, the application of criteria for the diagnosis of adult . . .