Unraveling Severe Sepsis
- 9 July 2003
- journal article
- editorial
- Published by American Medical Association (AMA)
- Vol. 290 (2) , 256-258
- https://doi.org/10.1001/jama.290.2.256
Abstract
In this issue of THE JOURNAL, Abraham and colleagues1 report the results of an international, multicenter randomized controlled trial (optimized phase 3 tifacogin in multicenter international sepsis trial [OPTIMIST]) that compared a 96-hour infusion of recombinant tissue factor pathway inhibitor (TFPI) with placebo in 1754 critically ill patients with sepsis and mild coagulopathy (international normalized ratio [INR] ≥1.2). Tissue factor pathway inhibitor, a naturally occurring anticoagulant, modulated the coagulation cascade but did not impact the mortality rate.Keywords
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