Further studies of effects of vehicles and elicitation concentration in experimental contact sensitization testing in humans

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Abstract
Further confirmation of the effects of vehicles and elicitation concentration in experimental contact sensitization testing with fragrance ingredient is reported. A dose-response relation was seen when sensitized human subjects were challenged with dihydrocoumarin, alantroot oil and diethylmaleate. Alcohol was a more effective vehicle than petrolatum when cinnamon bark oil, vetiver acetate and diethylmalleate were used in predictive tests. The relation of these findings to risk-benefit judgments is discussed briefly.