Miniaturized single-photon fluorometry

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Abstract
The authors report the miniaturization of single-proton timing fluorescence lifetime spectroscopy using picosecond diode laser excitation and liquid light guide collection of different time-correlated signals in a multiplexed arrangement. Liquid light guide coupling permits multiple channels of fluorescence decay information with respect to wavelength, polarization, sensor, etc., to be collected simultaneously and eliminates a common source of error in convolution analysis. The instrumental performance is demonstrated in a study of perylene fluorescence quenched by cobalt ions in micelles.