Interstitial Pneumonitis Associated with Sirolimus Therapy in Renal-Transplant Recipients

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To the Editor: Morelon et al. (July 20 issue)1 described three patients in whom interstitial pneumonitis was thought to be related to sirolimus therapy, because it occurred during therapy and resolved after sirolimus was discontinued and because other causes were absent.To date, the Food and Drug Administration (FDA) has received reports of 34 cases of interstitial pneumonitis that were temporally associated with sirolimus therapy (including the 3 described by Morelon et al.). All but two case reports2 were from clinical studies of sirolimus. Thirty-two patients were being treated with sirolimus after receiving kidney transplants, one after receiving a liver . . .