Cyanocobalamin-Dependent Depression of the Serum Alkaline Phosphatase Level in Patients with Pernicious Anemia
- 10 September 1964
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 271 (11) , 541-544
- https://doi.org/10.1056/nejm196409102711104
Abstract
LOWERING of the serum alkaline phosphatase activity has received little attention.1 It is known in scurvy and hypophosphatasemia and after exposure to radioactive substances that are deposited in bone. In children the serum alkaline phosphatase falls to adult levels when the skeletal growth is disturbed (as in achondroplasia or cretinism).2 We observed a patient suffering from both pernicious anemia and Paget's disease. The serum phosphatase level was normal and increased to abnormal height only after administration of vitamin B12.One possible explanation of these facts was that osteoblastic activity had been depressed by vitamin B12 deficiency. If . . .Keywords
This publication has 7 references indexed in Scilit:
- Reversible Hypogammaglobulinaemia in Cyanocobalamin (B12) DeficiencyActa Medica Scandinavica, 2009
- ISO-enzyme patterns of serum alkaline phosphatase in agar-gel electrophoresis and their clinical significanceClinica Chimica Acta; International Journal of Clinical Chemistry, 1963
- Alkaline Phosphatase in Human Sera and PlacentaeScience, 1961
- Serum alkaline phosphatase activity in diseases of the skeletal and hepatobiliary systems: A consideration of the current statusThe American Journal of Medicine, 1959
- Tissue Sources of Human Serum Alkaline Phosphatase, as Determined by Immunochemical ProceduresJournal of Biological Chemistry, 1959
- Differentiation into Three Fractions of the Serum Alkaline Phosphatase and the Behavior of the Fractions in Diseases of Bone and LiverScandinavian Journal of Clinical and Laboratory Investigation, 1959
- Amino‐Acid and Protein Metabolism in Pernicious AnaemiaBritish Journal of Haematology, 1958