Effect of a New LH-RH Analogue (D-Ser(TBU)6-EA10-LH-RH) on Gonadotrophin and Gonadal Steroid Secretion in Men

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Abstract
The effect of a new analogue of the gonadotrophin-releasing hormone LH-RH, D-Ser(TBU)6-EA10-LH-RH, on the secretion of LH, FSH, as well as testosterone, oestrone, oestradiol, HGH, prolactin, TSH, and cortisol was studied in normal men. The same subjects were injected intravenously in 4-day intervals with 1.0, 2.5, 5.0, and 10.0 µg of this substance. A significant LH but no FSH release was seen after doses of 1.0 and 2.5 µg LH-RH analogue, while after 5.0 and 10.0 µg dose-dependent increases of LH and imposed elevations of FSH were observed. Peak levels of LH were reached after 30 min, those of FSH after intravenous injection after 120 min. LH and FSH remained elevated for 8–10 h. LH peak levels after 5 µg of LH-RH analogue were comparable to those seen after injection of 100 µg of the decapeptide LH-RH. Following the release of LH and FSH after doses of 5.0 and 10.0 µg LH-RH analogue, there was a late stimulating effect in testosterone and oestradiol secretion. HGH, TSH, prolactin, and cortisol were not influenced by the LH-RH analogue.

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