The effect of glucagon and glucagon 1-21 on anal sphincter function

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Abstract
Resting anal sphincter pressure and rectoanal reflex were studied in 6 healthy volunteers after administration of placebo, glucagon and glucagon 1-21. Glucagon resulted in a marked but short-lived early decrease in resting anal pressure, whereas the 1-21 fragment of the glucagon molecule had no effect. Further investigation of the possible hormonal/peptidergic regulation of anal sphincter function is necessary.