Halothane-Induced Liver Damage — An Entity
- 6 March 1969
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 280 (10) , 558-559
- https://doi.org/10.1056/nejm196903062801010
Abstract
THERE is considerable controversy about whether hepatic injury is induced by exposure to halothane. In support of the existence of such an entity are reports in the literature by 1967 of approximately 400 cases of liver damage after halothane anesthesia.1 In general, the reaction was severe, with death the outcome in approximately a third of the patients. Symptoms and signs, with fever a prominent feature, usually appeared within the first week after the most recent exposure to the anesthetic, but at times delayed for two or three weeks. Physical findings and results of laboratory tests resembled those found in many . . .Keywords
This publication has 4 references indexed in Scilit:
- Fulminant Hepatic FailureNew England Journal of Medicine, 1968
- HALOTHANE HEPATITIS IN AN ANqSTHETISTThe Lancet, 1966
- Summary of the National Halothane StudyJAMA, 1966
- DRUG-INDUCED HEPATIC INJURYAnnals of Internal Medicine, 1959