Heparin induced thrombocytopenia thrombosis (HIT/T) syndrome: diagnosis and treatment
Open Access
- 1 April 2001
- journal article
- review article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 54 (4) , 272-274
- https://doi.org/10.1136/jcp.54.4.272
Abstract
Heparin induced thrombocytopenia thrombosis (HIT/T) is associated with a high morbidity and mortality. Diagnosis is essentially clinical and negative results of laboratory assays do not exclude the diagnosis. Treatment involves stopping all heparin immediately and giving an alternative thrombin inhibitor. The adoption of low molecular weight heparins is one reason for the reduced incidence of this disease in recent years.Keywords
This publication has 26 references indexed in Scilit:
- Heparin-induced thrombocytopeniaBlood Reviews, 1999
- Recombinant Hirudin (Lepirudin) Provides Safe and Effective Anticoagulation in Patients With Heparin-Induced ThrombocytopeniaCirculation, 1999
- Anticoagulation with Novastan®(Argatroban) in Patients with Heparin-Induced Thrombocytopenia and Heparin-Induced Thrombocytopenia and Thrombosis SyndromeSeminars in Thrombosis and Hemostasis, 1997
- A diagnostic test for heparin‐induced thrombocytopenia: detection of platelet microparticles using flow cytometryBritish Journal of Haematology, 1996
- Use of enoxaparin in patients with heparin-induced thrombocytopenia syndromeJournal of Vascular Surgery, 1996
- AnnotationBritish Journal of Haematology, 1995
- Laboratory diagnosis of heparin‐associated thrombocytopenia and comparison of platelet aggregation test, heparin‐induced platelet activation test, and platelet factor 4/heparin enzyme‐linked immunosorbent assayTransfusion, 1994
- Platelet aggregation in response to four low molecular weight heparins and the heparinoid ORG 10172 in patients with heparin‐induced thrombocytopeniaBritish Journal of Haematology, 1994
- Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells.Journal of Clinical Investigation, 1994
- Immune Endothelial-Cell Injury in Heparin-Associated ThrombocytopeniaNew England Journal of Medicine, 1987