Method for evaluating spasmolytic activity of drugs on the bile duct

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Abstract
A method has been described for examining the spasmolytic activity of drugs on the bile duct of the guinea-pig in situ. The terminal bile duct was pulled away from its insertion into the duodenum and perfused with Tyrode solution containing either carbachol or barium chloride to produce spasm. Injected intravenously, atropine methonitrate, oxyphencyclimine hydrochloride, tropenziline bromide, phenetamine, papaverine hydrochloride or diprophylline were spasmolytic.