Mismatch between insulin-mediated glucose uptake and blood flow in the heart of patients with Type II diabetes
- 1 October 2002
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 45 (10) , 1404-1409
- https://doi.org/10.1007/s00125-002-0917-3
Abstract
Aims/hypothesis. We investigated the effect of physiological hyperinsulinaemia on global and regional myocardial blood flow and glucose uptake in five patients with Type II (non-insulin-dependent) diabetes mellitus and seven healthy control subjects. Methods. Myocardial blood flow was assessed by positron emission tomography with oxygen-15 labelled water (H2 15O) either before or after 1 h of euglycaemic hyperinsulinaemia. Myocardial glucose uptake was assessed by positron emission tomography and fluorine-18 labelled fluorodeoxyglucose (18FDG). Results. During hyperinsulinaemia, myocardial blood flow increased from 0.91±0.03 to 1.00±0.03 ml.min–1.g–1 in control subjects (p.min–1.g–1 in diabetic patients (p.min–1.g–1 (pConclusion/interpretation. These results provide evidence that insulin-mediated regulation of global myocardial blood flow is preserved in Type II diabetic patients. In contrast, the regional re-distribution of myocardial blood flow induced by insulin is directed to different target areas when compared with healthy subjects, thereby resulting in a mismatch between blood flow and glucose metabolism.Keywords
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