ANIMAL-MODEL OF SENSITIZATION BY INHALATION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 24  (3) , 542-545
Abstract
Groups of rats exposed to daily inhalation challenge with aerosolized pigeon serum developed precipitating antibody within 2 wk and definitive granulomatous inflammatory changes in the lung after 7 wk of exposure. The dissociation of the 2 responses to an inhalation challenge indicate that the rat model may serve for screening of the various inhalant antigens for their sensitizing potential, and for investigation of the contributory role of some of the factors involved in the pathogenesis of hypersensitivity pneumonitis.