Absorption of medium-chain fatty acids by the dog colon.

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Abstract
The absorption of the Na salts of 3 medium-chain fatty acids (hexanoic, octanoic, and decanoic) from aqeous solutions was measured by their rate of disappearance from the solution during perfusion through an isolated colon loop of dogs. In 45 experiments the absorption rate from a recirculated solution containing 40 meq/I was the same for each of the fatty acids in 3 dogs. When related to surface area of the colonic loop, absorption in the 3 dogswas 0.016, 0.016, and 0.013 meq/cm2 per hr. The absorption of 1 of the medium-chain fatty acid salts, sodium octanoate, increased in a linear relation to the concentration of the salt in the perfusing solution (20, 30, and 40 meq/1). There was a constant rate of absorption, measured at 1/2-hr. intervals over a 2-hr. period, in a continuous perfusion study. The studies indicate a rate of absorption of medium-chain fatty acid from the dog colon that is appreciable and appears to amount to about 1/4 that reported for human jejunum.

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