EFFECT OF COMBINATION TREATMENT WITH CYCLOPHOSPHAMIDE AND NONSPECIFIC PASSIVE-IMMUNIZATION ON A TRANSPLANTABLE TUMOR IN WKA RATS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (7) , 2119-2123
Abstract
Combination of cyclophosphamide (CY) and passive immunization with lymphoid cells sensitized to allogeneic tumor was studied in the treatment of a methylcholanthrene-induced transplantable fibrosarcoma in WKA rats. For determination of the most effective timing of combination treatment, rats given an injection of CY on day 3 received passive transfer of the sensitized lymphoid cells on day 0, 1, 2, 3, 4 or 6. A remarkable therapeutic effect was observed only when the passive transfer was combined on day 4 with CY on day 3. Rats inoculated with tumor succumbed in all cases without any treatment. After i.v. injection of CY on day 3, 2 of 28 rats were cured (7.1%). Passive immunization with the sensitized lymphoid cells on day 4 resulted in no therapeutic effect. After combination of CY on day 3 and transfer of nonsensitized normal lymphoid cells on day 4, 2 of 15 rats survived (13.3%). Combination of CY and passive transfer of the nonspecifically sensitized lymphoid cells resulted in 23 survivors of 29 rats (79.3%).

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