THE EFFECT OF A SULFATED POLYSACCHARIDE ON ANTI-THROMBIN-III

  • 1 January 1980
    • journal article
    • research article
    • Vol. 95  (6) , 783-790
Abstract
A major naturally-occurring inhibitor of [human] blood is AT[antithrombin]-III. The potentiation of AT-III inhibition of factors Xa [bovine], IIa, and plasmin by the heparinoid substance SP-54 [sodium pentosan polysulfate] was studied. Both coagulation and amidolytic methods were used. SP-54 potentiated AT-III inhibition of factors Xa and IIa in the absence of heparin. When heparin was present, potentiation of inhibition of factor Xa usually occurred, but not of factor IIa. SP-54 potentiated the AT-III inhibition of plasmin action. Laurell immunoelectrophoresis showed no changes in AT-III in the presence of SP-54. In view of the recent importance placed on the role of AT-III and factor Xa in thrombogenesis, an oral agent which potentiates AT-III activity can have important implications for thrombotic therapy.

This publication has 3 references indexed in Scilit: