Reduced plasma c-AMP levels in children with atopic dermatitis
- 1 August 1998
- journal article
- Published by Wiley in Pediatric Allergy and Immunology
- Vol. 9 (3) , 130-132
- https://doi.org/10.1111/j.1399-3038.1998.tb00358.x
Abstract
Plasma levels of cAMP and serum concentrations of IgE have been determined in children with acute atopic dermatitis (AD) and in a healthy control group, to illuminate the pathophysiological mechanisms that cause AD. There were significantly lower plasma levels of cAMP (P < 0.001) and significantly higher levels of serum IgE (P < 0.004) in children with AD, in comparison with a healthy control group. It is possible that defective control of c-AMP levels could contribute to the immunopathogenesis of AD and monitoring levels may be of value in the clinical evaluation of the disease.Keywords
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