EXPERIMENTAL-INFECTION OF FATTENING PIGS WITH PSEUDORABIES (AUJESZKYS DISEASE) VIRUS - EFFICACY OF ATTENUATED LIVE-VIRUS AND INACTIVATED-VIRUS VACCINES IN PIGS WITH OR WITHOUT PASSIVE-IMMUNITY

  • 1 January 1985
    • journal article
    • research article
    • Vol. 46  (7) , 1498-1502
Abstract
The efficacies of attenuated live- and inactivated-virus vaccines against pseudorabies (PR) in fattening pigs were compared. Pigs born from vaccinated or nonvaccinated sows were vaccinated with 1 or the other vaccine and were challenge exposed at the end of the fattening period. The particular form of PR observed in fattening units in the field could be reproduced. A marked difference was seen between the control lot and the lots of the pigs vaccinated with the attenuated live- and inactivated-virus vaccines. The protection was real, but not absolute, in the vaccinated pigs. The inactivated-virus vaccine conferred a strong passive immunity to the young pigs of vaccinated dams which interfered with the development of an active immunity. The titer of the colostral antibodies in the sera of pigs born from the sows vaccinated with the attenuated-live virus vaccine was low and decreased rapidly. The active protection obtained with this vaccine was similar to that observed with the inactivated-virus vaccine. Thermal curves, wt losses, and time necessary for recovering the wt of pigs at the time of challenge exposure seemed to be good criteria for measuring the protection of fattening pigs against this particular form of PR. The conditions of the outcome of respiratory tract disorders in these pigs are discussed.