En BlocTransduction of Imipenem Resistance with Other Resistance Determinants from a Clinical Strain ofPseudomonas aeruginosa
- 1 January 1996
- journal article
- research article
- Published by Taylor & Francis in Journal of Chemotherapy
- Vol. 8 (1) , 43-46
- https://doi.org/10.1179/joc.1996.8.1.43
Abstract
In this report we describe a lysogenic strain of Pseudomonas aeruginosa No. 229, from Frankfurt University Clinics, resistant to imipenem (IMI), cefotaxime (CTX), kanamycin (KAN), carbenicillin (CAR) as well as to other non-beta-lactam drugs, from which a wild-type phage could be isolated and used for transduction of an imipenem resistance determinant. All IMI-selected transductants were found to be co-resistant also to CTX, KAN and CAR. Conversely, transductants selected with CTX, KAN or CAR were also all resistant to IMI. It seems probable that IMI is hydrolyzed by the original donor strain as well as by transductant colonies by means of a clavulanate-inhibited beta-lactamase and not by a metallo-beta-lactamase.Keywords
This publication has 2 references indexed in Scilit:
- Metallo-β-lactamases— new therapeutic challengeJournal of Medical Microbiology, 1993
- Imipenem and Cefotaxime Resistance: Transduction by Wild-Type Phages in Hospital Strains ofPseudomonas aeruginosaJournal of Chemotherapy, 1992