Effect of Dietary Fibre on Blood Glucose, Plasma Immunoreactive Insulin, C-peptide and GIP Responses in non Insulin Dependent (Type 2) Diabetics and Controls

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Abstract
A high fiber and a low fiber breakfast meal were given to 8 non-insulin dependent diabetics (NIDD) and 8 controls. Blood glucose response was monitored continuously for 3 h and characterized using a straight line model. After the high fiber meal the rates of increase and decrease in blood glucose concentration were slower both in diabetics and controls than after the low fiber meal. The delay time, i.e., the time from meal intake to the start of glucose increase, hypothetically corresponding to gastric emptying time, was the same after both test meals. The postprandial glucose increment calculated as the area under the 0-120 min curve was lower after the high fiber meal in the NIDD, but not in the controls. The 2-h C-peptide and gastric inhibitory polypeptide values were lower for the diabetics after the high fiber breakfast. Prolonged carbohydrate digestion and/or absorption after high fiber breakfast are indicated.