Pharmacokinetics and Efficacy of Pirmenol Hydrochloride in the Treatment of Ventricular Dysrhythmia

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Abstract
Summary Pirmenol hydrochloride (CI-845), a new antiarrhythmic agent available for both oral and intravenous administration, was given to seven patients with chronic ventricular dysrhythmia in an open-label fashion. After intravenous infusion of 150 mg over 30 min, the mean (± SD) peak plasma concentration achieved was 2.14 ± 0.75μ.g/ml. The terminal elimination half-life, the volume of the central compartment, and the total body clearance averaged 6.5 h, 0.70 ± 0.36 L/kg, and 3.0 ± 2.6 ml/min/ kg, respectively. After a single 150-mg oral dose, the peak plasma concentration of 1.3 ± 0.55 μg/ml was achieved 1 to 3 h after dosing. The mean apparent elimination half life was 7.6 h. An estimated absorption lag time ranging from 14 to 37 min was observed in all but one patient. The mean absolute bioavailability for the oral dose was 87%. Dysrhythmia data were available in six patients. Complete (100%) suppression of ventricular ectopic beats occurred in four patients for 1/2 to 15 h after intravenous infusion, and in three patients for 7 to 25 h after oral dose. This suppression occurred with a plasma pirmenol level as low as 0.4 μg/ml. No significant side effects were observed.

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